Skew in ovarian activation depends on domicile size in phyllode-glueing thrips

Costs and benefits of group living are a fundamental topic in behavioural ecology. Resource availability affects individuals’ breeding prospects alone and in groups, as well as how reproduction is distributed within groups (“reproductive skew”). Here, we provide correlational evidence in facultatively social thrips that breeding resources are associated with (1) whether solitary or social living is favoured, and (2) the degree of ovarian skew. Dunatothrips aneurae (Thysanoptera, Phlaeothripidae) cooperatively build silk “domiciles” on Australian Acacias, feeding exclusively from internal phyllode surfaces. Per capita productivity scaled differently with group size depending on domicile volume - females in small domiciles did better alone than in groups, whereas in large domiciles single and group-nesting females did equally well. Ovarian dissections revealed that in small domiciles some females were nonreproductive, indicating ovarian (i.e. reproductive) skew. Skew increased as domicile size decreased and group size increased. Breeders had smaller oocyte volume in smaller domiciles, especially those containing nonreproductives. These findings suggest group formation and reproductive skew in D. aneurae may be influenced by reproductive competition for breeding resources. Nonreproductive females in small domiciles may be reproductively suppressed, subfertile, or accumulating resources to reproduce

Academic chartered data safety committees versus industry sponsored data safety committees: The need for different recommendations

Dear Editor, We read with great interest the recently published paper by Calis et al.1 We applaud the authors and the working group for developing this important set of recommendations for data monitoring committees (DMC). Recommendations for organizing a DMC are long overdue. Our academic institution has had a formal DMC for many years which administratively reports to an academic official who directs the research efforts. It has a formal charter and broad membership that includes clinicians, clinical trial specialists, and a biostatistician. It accepts for review studies that require a DMC (usually phase II or III trials) and are not sponsored by industry, which usually set up their own DMC. Most studies are supported by the institution, US Government research funding sources (e.g. National Institutes of Health (NIH), Centers for Disease Control and Prevention), or research foundations

Historical model evaluation data requirements

Several studies about tank waste contents have been published using historical records of tank transactions and various analytical measurements. While these records offer a wealth of information, the results are questionable until error estimates associated with the results can be established. However, they do provide a direction for investigation. Two principal observations from the studies are: (1) Large quantities of individual waste types from the various separations processes were widely distributed throughout the tank farms, and (2) The compositions of many of these waste types are quite distinct from one another. A key assumption associated with these observations is that the effects of time and location on the tank wastes are either nominal or not discernable. Since each waste type has a distinct composition, it would benefit all programs to better quantify that composition, and establish an uncertainty for each element of that composition. Various process, disposal, or other decisions could then be made based on current information reducing the need for extended sampling and analysis

Discovery of a redshift 6.13 quasar in the UKIRT infrared deep sky survey

Original article can be found at: http://www.aanda.org/ Copyright The European Southern Observatory (ESO) DOI: 10.1051/0004-6361/200811161Optical and near-infrared (NIR) spectra are presented for ULAS J131911.29+095051.4 (hereafter ULAS J1319+0950), a new redshift z = 6.127 0.004 quasar discovered in the Third Data Release (DR3) of the UKIRT Infrared Deep Sky Survey (UKIDSS). The source has = 19.10 0.03, corresponding to = -27.12, which is comparable to the absolute magnitudes of the z 6 quasars discovered in the Sloan Digital Sky Survey (SDSS). ULAS J1319+0950 was, in fact, registered by SDSS as a faint source with = 20.13 0.12, just below the signal-to-noise ratio limit of the SDSS high-redshift quasar survey. The faint z-band magnitude is a consequence of the weak Ly /N V emission line, which has a rest-frame equivalent width of ~20Å and provides only a small boost to the z-band flux. Nevertheless, there is no evidence of a significant new population of high-redshift quasars with weak emission lines from this UKIDSS-based search. The Ly  optical depth to ULAS J1319+0950 is consistent with that measured towards similarly distant SDSS quasars, implying that results from optical- and NIR-selected quasars may be combined in studies of cosmological reionization. Also presented is a new NIR-spectrum of the previously discovered UKIDSS quasar ULAS J020332.38+001229.2, which reveals the object to be a broad absorption line quasar. The new spectrum shows that the emission line initially identified as Ly  is actually N V, leading to a revised redshift of z = 5.72, rather than z = 5.86 as previously estimatedPeer reviewe

Where does prepotency come from on developmental tests of inhibitory control?

Understanding the processes that make responses prepotent is central to understanding the role of inhibitory control in cognitive development. The question of what makes responses prepotent was investigated using the two most widely studied measures of preschoolers' inhibitory control. Across two experiments, 80 children were tested either on a series of stimulus-response compatibility (SRC) tasks or on a series of Go/No-go tasks. Results indicated that high levels of prepotency on SRC tasks (such as the Day/Night task) occur only under specific conditions; making a verbal response can be highly prepotent if the stimulus and response are associated with each other (e.g., saying "cup" to a cup) but is less prepotent when they are unassociated (e.g., saying "cup" to a doorstop). Action responses (e.g., lifting a cup to your mouth) show little prepotency irrespective of whether the stimulus and response are associated. In contrast, with Go/No-go tasks, a much wider variety of behaviors are highly prepotent regardless of whether the stimulus and response are associated. These data suggest that prepotency arises in very different ways, depending on the type of task used. Although both Go/No-go tasks and SRC tasks can make inhibitory demands, they do so for fundamentally different reasons

Can we boost preschoolers’ inhibitory performance just by changing the way they respond?

Changing the way children make their response appears to sometimes, but not always, boost their inhibitory control—though interpreting existing findings is hampered by inconsistent methods and results. This study investigated the effects of delaying, and changing, the means of responding. Ninety-six preschoolers (Mage 46 months) completed tasks assessing inhibitory control, counterfactual reasoning, strategic reasoning, and false belief understanding. Children responded either immediately or after a delay, and either by pointing with their finger, or with a hand-held arrow. Delaying boosted performance on all tasks except false belief understanding; arrow-pointing only improved strategic reasoning. It is suggested that delay helps children work out the correct response; it is unlikely to help on tasks where this requirement is absent

Adult beginner distance language learner perceptions and use of assignment feedback

This qualitative study examines perceptions and use of assignment feedback among adult beginner modern foreign language learners on higher education distance learning courses. A survey of responses to feedback on assignments by 43 Open University students on beginner language courses in Spanish, French, and German indicated that respondents can be classified into three groups: those who use feedback strategically by integrating it into the learning process and comparing it with, for example, informal feedback from interaction with native speakers, those who take note of feedback, but seem not to use it strategically, and those who appear to take little account of either marks or feedback. The first group proved to be the most confident and most likely to maintain their motivation in the longer term. The conclusion discusses some of the pedagogical and policy implications of the findings

Assessment of hydropyrolysis as a method for the quantification of black carbon using standard reference materials

A wide selection of thermal, chemical and optical methods have been proposed for the quantification of black carbon (BC) in environmental matrices, and the results to date differ markedly depending upon the method used. A new approach is hydropyrolysis (hypy), where pyrolysis assisted by high hydrogen pressures (150 bar) facilitates the complete reductive removal of labile organic matter, so isolating a highly stable portion of the BC continuum (defined as BChypy). Here, the potential of hypy for the isolation and quantification of BC is evaluated using the 12 reference materials from the International BC Ring Trial, comprising BC-rich samples, BC-containing environmental matrices and BC-free potentially interfering materials. By varying the hypy operating conditions, it is demonstrated that lignocellulosic, humic and other labile organic carbon material (defined as non-BChypy) is fully removed by 550 °C, with hydrogasification of the remaining BChypy not commencing until over 575 °C. The resulting plateau in sample mass and carbon loss is apparent in all of the environmental samples, facilitating BC quantification in a wide range of materials. The BChypy contents for all 12 ring trial samples fall within the range reported in the BC inter-comparison study, and systematic differences with other methods are rationalised. All methods for BC isolation, including hypy are limited by the fact that BC cannot be distinguished from extremely thermally mature organic matter; for example in high rank coals. However, the data reported here indicates that BChypy has an atomic H/C ratio of less than 0.5 and therefore comprises a chemically well-defined polyaromatic structure in terms of the average size of peri-condensed aromatic clusters of >7 rings (24 carbon atoms), that is consistent across different sample matrices. This, together with the sound underlying rationale for the reductive removal of labile organic matter, makes hypy an ideal approach for matrix independent BC quantification. The hypy results are extremely reproducible, with BChypy determinations from triplicate analyses typically within ±2% across all samples, limited mainly by the precision of the elemental analyser

Patient ethnicity and three psychiatric intensive care units compared: the Tompkins Acute Ward Study

Background: Psychiatric Care Units provide care to disturbed patients in a context of higher security and staffing levels. Although such units are numerous, few systematic comparisons have been made, and there are indications that ethnic minority groups may be over-represented. Aim: To compare the rates of adverse incidents and patterns of usage of three Psychiatric Intensive Care Units. Method: The study used a triangulation or multi-method design, bringing together data from official statistics, local audit and interviews conducted with staff. Results: Intensive care patients were more likely to be young, male, and suffering a psychotic disorder, as compared to general acute ward patients. Caribbean patients were twice as likely, and Asian patients half as likely, to receive intensive care (age, gender and diagnosis controlled). There were large differences in service levels, staffing, team functioning and adverse incidents between the three units. Various aspects of physical security were important in preventing absconds. Conclusions: More evaluative research is required in order to define effective service levels, and to explore the nature of the interaction between ethnicity and inpatient care provision during acute illness

RNA-Seq profiling of neutrophil-derived microvesicles in Alzheimer’s disease patients identifies a miRNA signature that may impact blood–brain barrier integrity

(1) Background: Systemic infection is associated with increased neuroinflammation and accelerated cognitive decline in AD patients. Activated neutrophils produce neutrophil-derived microvesicles (NMV), which are internalised by human brain microvascular endothelial cells and increase their permeability in vitro, suggesting that NMV play a role in blood–brain barrier (BBB) integrity during infection. The current study investigated whether microRNA content of NMV from AD patients is significantly different compared to healthy controls and could impact cerebrovascular integrity. (2) Methods: Neutrophils isolated from peripheral blood samples of five AD and five healthy control donors without systemic infection were stimulated to produce NMV. MicroRNAs isolated from NMV were analysed by RNA-Seq, and online bioinformatic tools were used to identify significantly differentially expressed microRNAs in the NMV. Target and pathway analyses were performed to predict the impact of the candidate microRNAs on vascular integrity. (3) Results: There was no significant difference in either the number of neutrophils (p = 0.309) or the number of NMV (p = 0.3434) isolated from AD donors compared to control. However, 158 microRNAs were significantly dysregulated in AD NMV compared to controls, some of which were associated with BBB dysfunction, including miR-210, miR-20b-5p and miR-126-5p. Pathway analysis revealed numerous significantly affected pathways involved in regulating vascular integrity, including the TGFβ and PDGFB pathways, as well as Hippo, IL-2 and DNA damage signalling. (4) Conclusions: NMV from AD patients contain miRNAs that may alter the integrity of the BBB and represent a novel neutrophil-mediated mechanism for BBB dysfunction in AD and the accelerated cognitive decline seen as a result of a systemic infection